A randomized open-label trial of a novel anti-sensitivity dentifrice versus popular brand

Abstract

Objective: Dentinal sensitivity is a common complaint that dentists deal with in their practice. Despite agents already in use, the search for more effective agents continues. The purpose of this study was to compare the effectiveness in the relief of dentinal sensitivity, taste and tissue-friendliness of a novel anti- sensitivity dentifrice with a known popular brand. Methods: A randomized mixed design with one between-subjects factor namely dentifrice group and one within-subjects factor namely, time. A two- point (four weeks apart) evaluation of dentinal sensitivity using a tactile stimulated response and subject-reported visual analogue scale scores. Data were analyzed using non-parametric alternatives due to violation of normality laws by post-treatment VAS data. Taste and adverse reactions were also compared.

Results: Both agents provided excellent relief from dentinal sensitivity except in two patients. Anti-sensitivity effectiveness judged by tactile stimulated, patient-reported VAS was similar between the two groups. There were no statistically-significant differences in effectiveness of relief from dentinal sensitivity. The taste of the popular brand was slightly better and there were no adverse effects. There were no adverse reactions recorded from either group.

Conclusion: The novel dentifrice was as effective as the popular brand in the relief of dentinal sensitivity.